The In vivo Biochemical and Oxidative Changes by Ethanol and Opium Consumption in Syrian Hamsters

Mohammadi, Abbas and Mirzaei, Fateme and Jamshidi, Mohammad and Yari, Reza and Pak, Solmaz and Sorkhani, Arash Noori and Norouzian, Parham and Abdolkarimi, Vahideh and Oshaghi, Ebrahim Abbasi (2013) The In vivo Biochemical and Oxidative Changes by Ethanol and Opium Consumption in Syrian Hamsters. International Journal of Biology, 5 (4). pp. 14-22. ISSN 1916-9671

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Abstract

Daily consumption of opium and alcohol can make people have many health problems, including coronary artery disease diseases (CAD) which has been found to be the most common cause death in opium addicts. The aim of this study was to investigate the effect of simultaneous consumption of alcohol and opium on the lipid profile and oxidative stress in Syrian golden hamsters. Twenty-four male golden Syrian hamsters were randomly divided into four treatment groups (n=6): 1-control (received normal chow), 2-opium (received 40 mg/kg of opium two times per day), 3-alcohol (received 6.0 g/kg of 30% ethanol two times per day), 4-combination group (received a combination of the above mentioned doses of opium and ethanol). After one month of treatment, hamsters were sacrificed and blood samples were collected. Lipid levels and atherogenic index were markedly increased in the combination group compared with the controls (p < 0.001). Serum alanine aminotransferase (ALT) (p < 0.05), aspartate aminotransferase (AST) (p < 0.05), and gamma-glutamyl transferase (GGT) (p < 0.01), were significantly increased in alcohol-treated group compared with the control animals. The increase in ALT (p < 0.01) and GGT (p < 0.001) levels were more significant in the combination group when compared with the controls. The plasma concentration of malondialdehyde (MDA) was markedly increased in the ethanol (p < 0.01), opium (p < 0.01) and combination groups (p < 0.001) compared with the controls. Glutathione (GSH), nitric oxide (NO) and catalase (CAT) levels as well as superoxide dismutase activity were markedly reduced in the ethanol (p < 0.05), opium (p < 0.05), and combination groups (p < 0.001) compared with the control group. Results of this study clearly showed that opium and ethanol are capable to provoke the oxidative stress when administered alone or in combination. Moreover, combination opium and alcohol increased total cholesterol, LDL-C, TG, VLDL-C, atherogenic index and non-HDL-C levels.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 24 May 2023 07:38
Last Modified: 01 Feb 2024 04:26
URI: http://stm.e4journal.com/id/eprint/1023

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