Abdollahi, Alireza and F, Ensani and Z, Maleki and G, Iravanlo and A, Ashtari (2011) Differential expression of e-cadherin in lobular and ductal carcinoma of breast in an Iranian Cancer Care Hospital. Pakistan Journal of Medical Sciences, 27 (1). pp. 56-59.
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Abstract
Objective: To determine the role of E-cadherin in differentiating Breast lobular carcinoma from Breast ductal carcinoma in Iranian patients.
Methodology: A total of 80 malignant breast samples were reviewed by two pathologists before undergoing E-cad immunohistochemistry (IHC) staining. The results from IHC were compared with the results from the morphological study of the samples and they were then analyzed statistically.
Results: The normal ductal cells had strong complete homogenous membrane E-cadherin reactivity in all cases. The complete absence of E-cadherin membrane staining occurred in 14 out of 16 cases of Lobular breast carcinoma. The mean score of E-cadherin expression in ductal carcinoma was 191.35 with a CV of 104.39. In lobular carcinoma, the mean score of E-cadherin was 9.36 with a CV of 25.68. Using the Mann Whiteny test, the difference between E-cadherin expression score in ductal and lobular carcinoma was statistically significant (P=0.0009).
Conclusion: E-cadherin expression is a useful diagnostic tool in distinguishing ductal from lobular carcinoma of breast.
| Item Type: | Article |
|---|---|
| Subjects: | Open Research Librarians > Medical Science |
| Depositing User: | Unnamed user with email support@open.researchlibrarians.com |
| Date Deposited: | 20 Feb 2023 10:06 |
| Last Modified: | 02 Oct 2023 12:45 |
| URI: | http://stm.e4journal.com/id/eprint/113 |
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