Cortical Spreading Depolarizations in the Context of Subarachnoid Hemorrhage: A Review

Amaral, Leandro Custódio do (2021) Cortical Spreading Depolarizations in the Context of Subarachnoid Hemorrhage: A Review. In: Recent Developments in Medicine and Medical Research Vol. 3. B P International, pp. 143-151. ISBN 978-93-5547-086-7

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Abstract

Delayed cerebral ischemia (DCI) is one of the main complications of spontaneous subarachnoid haemorrhage and one of its causes is the cortical spreading depolarizations (CSDs). Cortical spreading depolarizations are waves of neuronal and glial depolarizations in which there is loss of neuronal ionic homeostasis with potassium efflux and sodium and calcium influx. CSDs in the cerebral cortex are involved in the pathogenesis both of acute ischemia and delayed cerebral ischemia after Aneurysmal subarachnoid haemorrhage (aSAH). In damaged brain areas and brain areas at risk, such as those adjacent to subarachnoid haemorrhage (SAH), CSDs induce microvascular vasoconstriction and, therefore, hypoperfusion and spread of ischemia. Several studies have been devoted to minimize secondary injuries that occur hours to days after an acute insult. Ketamine, a drug until recently contraindicated in the neurosurgical population for potentially causing intracranial hypertension, has re-emerged as a potential neuroprotective agent due to its pharmacodynamic effects at the cellular level. These effects include anti-inflammatory mechanisms, and those of microthrombosis and cell apoptosis controls, and of modulation of brain excitotoxicity and CSDs. Retrospective studies confirmed the effects of ketamine on the control of CSDs and, consequently, of DCI in patients with SAH, but did not show improvement in clinical outcome. The influence of ketamine on the occurrence/development of DCI needs to be further confirmed in prospective randomized studies.

Item Type: Book Section
Subjects: Open Research Librarians > Medical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 26 Oct 2023 04:48
Last Modified: 26 Oct 2023 04:48
URI: http://stm.e4journal.com/id/eprint/1829

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