Antimicrobial Activity of Newly Synthesized Thiabendazoles

Patil, Siddappa A. and Patil, Vikrant and Patil, Renukadevi and Bugarin, Alejandro and Patil, Shivaputra A. (2021) Antimicrobial Activity of Newly Synthesized Thiabendazoles. In: Current Advances in Chemistry and Biochemistry Vol. 2. B P International, pp. 1-13. ISBN 978-93-90768-44-8

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Abstract

In the present work, three new thiabendazole derivatives (4b and 6a-c) and their intermediates (3a-b) were synthesised by the reaction of inexpensive easily available amines with 4-cyanothiazole in moderate to good yields. The preliminary in vitro antimicrobial evaluation was conducted for all the compounds (3a-b, 4b and 6a-c) by the whole cell growth inhibition assays method towards Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia, Acinetobacter baumannii, Pseudomonas aeruginosa, Candida albicans and Cryptococcus neoformansvar. Our research efforts identified the highly potent antibacterial agent 3b which displayed strong growth inhibition (77.12%) towards gram-negative bacteria Acinetobacter baumannii.

Item Type: Book Section
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 02 Nov 2023 11:49
Last Modified: 02 Nov 2023 11:49
URI: http://stm.e4journal.com/id/eprint/1944

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