Application of Antioxidants as Effective Remedies at Hepatotoxic Action of Carbon Tetrachloride

The liver, as the central metabolic organ, plays an important role in metabolism of carbohy-drates,
lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical
toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural
changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract
(GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive
factors, the liver has a high regeneration ability. Thus, the model of liver toxicity and the LC, based on
the nature of ultrastructural changes of mitochondria and other compartments of hepatocytes, GSE,
as well as α-T and STS, have corrective effect. TEM ultrastructural characterization of the GSE
influence is evidence of its success cytoprotective and antitoxic features as well as hepatocytes from
xenobiotic-CCl4 induced by cirrhosis rat liver.