Hovnanyan, Karlen and Mamikonyan, Vardan and Margaryan, Anahit and Sargsyan, Kristine and Hovnanyan, Margarita and Karagyozyan, Maria and Karageuzyan, Konstantin (2020) Application of Antioxidants as Effective Remedies at Hepatotoxic Action of Carbon Tetrachloride. In: Current Research and Development in Chemistry Vol. 4. B P International, ▓178-182. ISBN 978-93-90206-42-1
Full text not available from this repository.Abstract
The liver, as the central metabolic organ, plays an important role in metabolism of carbohy-drates,
lipids and proteins. In the environment, there are many hepatotoxic xenobiotics. CCl4 is a free radical
toxic for organelles of hepatocytes. The presented work was studying the character of ultrastructural
changes in CCl4-intoxicated hepatocytes as well as the tissue after treatment by grape seed extract
(GSE), α-tocopherol (α-T). As a result of cell bioremediation effect and reactions against corruptive
factors, the liver has a high regeneration ability. Thus, the model of liver toxicity and the LC, based on
the nature of ultrastructural changes of mitochondria and other compartments of hepatocytes, GSE,
as well as α-T and STS, have corrective effect. TEM ultrastructural characterization of the GSE
influence is evidence of its success cytoprotective and antitoxic features as well as hepatocytes from
xenobiotic-CCl4 induced by cirrhosis rat liver.
Item Type: | Book Section |
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Subjects: | Open Research Librarians > Chemical Science |
Depositing User: | Unnamed user with email support@open.researchlibrarians.com |
Date Deposited: | 09 Nov 2023 06:17 |
Last Modified: | 09 Nov 2023 06:17 |
URI: | http://stm.e4journal.com/id/eprint/2022 |