Role of Some Apoptotic Proteins in Pathogenesis of Juvenile Systemic Lupus Erytheromatosis and Lupus Nephritis

Hanna, Anne Albir Aziz and Abdelnabi, Hend Hassan and Kholoussi, Naglaa Mohamed and Hana, Nagy Mohamed Abu El (2022) Role of Some Apoptotic Proteins in Pathogenesis of Juvenile Systemic Lupus Erytheromatosis and Lupus Nephritis. Journal of Advances in Medicine and Medical Research, 34 (21). pp. 272-282. ISSN 2456-8899

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Abstract

Background: Apoptosis is increased in Systemic Lupus Erytheromatosis (SLE) patients with defective clearance of apoptotic cells, which lead to a pathological accumulation of abnormal cell debris and provide an autoimmune reaction. The aim of this work was to evaluate apoptosis and CD4/CD8 ratio in juvenile SLE patients and their relation to disease activity and lupus nephritis (LN).

Methods: This case-control study included 50 patients with jSLE divided into two groups according to SLEDAI score and twenty-five healthy children of matched age and sex as controls. All cases were subjected to detection of apoptosis, in the early stage through investigation of Annexin V and CD4/CD8 ratio through CD4 and CD8 T cells monoclonal antibody using the BD Accuri™ C6 Flow Cytometer Instrument.

Results: early apoptosis has statistically significant increase in the jSLE patients compared to controls with positive correlation to disease activity and no correlation to LN. (active group 20.77± 7.88, inactive group13± 6.8 and controls3.53± 1.26). CD4/CD8 ratio has significant decrease in patients compared to controls with inversed correlation to disease activity and no correlation to LN. (active group1.28 ± 0.51, inactive group1.6 ± 00.6 and controls 2.1 ± 0.6.

Conclusions: Apoptosis is high in jSLE patients with low CD4/CD8 ratio which related to disease activity, but not related to LN.

Item Type: Article
Subjects: Open Research Librarians > Medical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 14 Mar 2023 12:28
Last Modified: 29 Feb 2024 04:28
URI: http://stm.e4journal.com/id/eprint/366

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