Appetitive behavioral traits and stimulus intensity influence maintenance of conditioned fear

Olshavsky, Megan E. and Jones, Carolyn E. and Lee, Hongjoo J. and Monfils, Marie-H. (2013) Appetitive behavioral traits and stimulus intensity influence maintenance of conditioned fear. Frontiers in Behavioral Neuroscience, 7. ISSN 1662-5153

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Abstract

Individual differences in appetitive learning have long been reported, and generally divide into two classes of responses: cue- vs. reward-directed. The influence of cue- vs. reward-directed phenotypes on aversive cue processing, is less well understood. In the current study, we first categorized rats based on their predominant cue-directed orienting responses during appetitive Pavlovian conditioning. Then, we investigated the effect of phenotype on the latency to exit a familiar dark environment and enter an unfamiliar illuminated open field. Next, we examined whether the two phenotypes responded differently to a reconsolidation updating manipulation (retrieval+extinction) after fear conditioning. We report that the rats with a cue-directed (“orienting”) phenotype differentially respond to the open field, and also to fear conditioning, depending on US-intensity. In addition, our findings suggest that, regardless of appetitive phenotype or shock intensity, extinction within the reconsolidation window prevents spontaneous recovery of fear.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 17 Mar 2023 09:28
Last Modified: 02 May 2024 09:43
URI: http://stm.e4journal.com/id/eprint/399

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