Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice

Bisong, S. A. and Mfem, C. C. and Nku, C. O. and Ajiwhen, I. O. and Osim, E. E. (2019) Long-term Consumption of Kola-nut (Cola nitida) Diet Does Not Increase Anxiety Related Behaviour in Mice. Asian Journal of Research in Medical and Pharmaceutical Sciences, 6 (1). pp. 1-8. ISSN 24570745

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Abstract

Following long-term consumption of kola nut (Cola nitida) diet, anxiety related behaviour were studied in 16 Swiss white mice (18-28g body weight). The open field (OF) test, elevated plus maze EPM) and the light/light transition box (LD) tests were used. Swiss white mice were fed either control diet (rodent chow; n=8) or kola nut diet (50% w/w kola-nut diet; n=8) for 28 days. All animals were allowed free access to clean drinking water. Results showed that the frequency of rearing in the kola nut diet group was lower (p< 0.05) compared to control. The non-exploratory behaviours like grooming and genital licking were also lower in the test group compared to control (p<0.001, 0.05 respectively). In the EPM test, the duration in the open arm in the kola diet group was higher compared to control (p< 0.01). The duration of grooming in the test group was however higher in the closed arm compared with control (p< 0.01). The frequency of downward dips only correlated positively with the duration in the open arm in the control [r (16) = 0.855; p< 0.01]. The kola fed animals spent more time in the light region of the LD test (p< 0.01) rearing and walling (p<0.05), and spent less time in the dark region when compared with their control. In conclusion, long-term consumption of kola nut diet decreased anxiety–related behaviour in the mice.

Item Type: Article
Subjects: Open Research Librarians > Medical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 15 Apr 2023 10:00
Last Modified: 27 Feb 2024 04:37
URI: http://stm.e4journal.com/id/eprint/607

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