Begum, Zahra and Khan, Momin and Khan, Sher Wali and Imran, Muhammad and Rehman, Noor and Umar, Muhammad Naveed and Kamil, Atif and Muhammad, Turghun (2019) Synthesis, Characterization, Antifungal and Antibacterial Activities of Novel Amide Derivatives of 1,3-Dioxolane. International Journal of Chemistry, 11 (1). p. 71. ISSN 1916-9698
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Abstract
L-Tartaric acid which is chiral compound and commercially available, was converted into 1,3-dioxolane. In the synthetic sequence, 1,3-dioxolane was first formed via protection and partial hydrolysis of L-tartaric acid. Treatment with altered substituted aromatic amines, 1,3-dioxolane gave the desired amides i.e. ethyl 2,2-dimethyl-5-(phenylcarbamoyl)-1,3-dioxolane-4-carboxylate 3a,
2-(4-(ethoxycarbonyl)-2,2-dimethyl-1,3-dioxolane-5-carboxamido)benzoic acid 3b, ethyl
5-(4-iodophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3c, ethyl
5-(2-chlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3d and ethyl
5-(2,4-dichlorophenylcarbamoyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 3e. These chiral derivatives were purified through column chromatographic technique and characterized by different spectroscopic techniques i.e IR, 1H NMR, 13C NMR and EIMS. The antimicrobial activities of these compounds were determined at different concentrations against different strains of bacteria and fungi.
Item Type: | Article |
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Subjects: | Open Research Librarians > Chemical Science |
Depositing User: | Unnamed user with email support@open.researchlibrarians.com |
Date Deposited: | 19 Apr 2023 09:24 |
Last Modified: | 01 Mar 2024 04:19 |
URI: | http://stm.e4journal.com/id/eprint/708 |