Influence of Flaxseed on Lipid Profiles and Expression of LXRa, in Intestine of Diabetic Rat

Mohammadi, Abbas and Mirzaei, Fateme and Jamshidi, Mohammad and Yari, Reza and Pak, Solmaz and Norouzian, Parham and Abdolkarimi, Vahideh and Oshaghi, Ebrahim Abbasi (2013) Influence of Flaxseed on Lipid Profiles and Expression of LXRa, in Intestine of Diabetic Rat. International Journal of Biology, 5 (4). pp. 23-28. ISSN 1916-9671

[thumbnail of 28340-101345-1-PB.pdf] Text
28340-101345-1-PB.pdf - Published Version

Download (214kB)

Abstract

The aim of this study is to examine the effect of flaxseed on lipid profiles in diabetic rats, focusing on intestinal LXR a. Animals were randomly divided into 3 groups of 8 rats each. group1: rats + chow diet (control), group 2: diabetic rats + chow diet (diabetic control), and group3: diabetic rats + chow diet + 4% flaxseed (w/w) (flaxseed group). After one-month rats were sacrificed, blood was collected; lipid profiles were determined enzymatically as well as mRNA and protein levels of SR-BI were determined by RT-PCR and westernblot respectively. Compared with diabetic control (group 2), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides, and very low density lipoprotein cholesterol (VLDL-C) (all of them P < 0.01) significantly decreased in flaxseed group (group 3). Intestinal LXR a mRNA was significantly increased (P < 0.001) in flaxseed group treatment compared with diabetic animals (group 2). Levels of intestinal regulatory protein of LXR a significantly increased in flaxseed group (P < 0.05). In conclusion, flaxseedsignificantly reduced TC, LDL-C, TG, VLDL-C and atherogenic index, as compared with the diabetic rats (group 2). On the other hand flaxseed led to up-regulation of LXR a in the intestine of rats.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 24 May 2023 07:39
Last Modified: 31 Jan 2024 04:34
URI: http://stm.e4journal.com/id/eprint/1024

Actions (login required)

View Item
View Item