Biological Evaluation and Spectral Studies of Asymmetrical 3,5-Disubstituted-1,2,4-Oxadiazoles

In present communication, we report the synthesis of 3,5-disubstituted-1,2,4-oxadiazoles derivatives from amino acid derivative with excellent 80-95% yields via a fast and easy procedure under mild conditions. Structures of all the newly synthesized compounds were elucidated based on their elemental analyses and various spectroscopic methods. The in vitro activities of these compounds against bacteria and fungi were evaluated by the well diffusion and the minimum inhibitory concentration (MIC) methods. Some of the synthesized derivatives were found active as compare to standard drugs.