Incidence of Pulmonary Papillary Carcinoma in Dromedary Camels Affected with Pneumonia: A Sudanese First Report

Aims: To study the pathology of lung tissue affected with tumors and isolate, identify the bacteria associated with these tumors in dromedary camels in Sudan to investigate the relationship between tumor and bacteria.

Study: Design 45 lung samples of camels slaughtered at Tambool abattoir, Al-Gazeera state in Sudan of age ranging between 10-15 years, were subjected to pathological and bacteriological studies using standard methods.

Place of Study: This study was undertaken in the Departments of Pathology and Bacteriology, Central Veterinary Research Laboratories, Ministry of Animal Resources and Fisheries, Khartoum during 2015.

Methodology: The isolates were characterized using different techniques: conventional, Api kits and automated system Vitek 2 Compact. In histopathological method portions of Lungs tissues were fixed in 10% formalin, processed by standard method for paraffin wax embedding, 5 micron sections were cut and stained with hematoxylin and eosin (H and E).

Results: Four out of 45 lung samples (8.9%) were diagnosed as pulmonary papillary carcinoma. The most striking changes were complete obliteration of lungs tissues architecture, which were replaced with papillary fibrovascular projections with complex secondary and tertiary branches. The cells lined projections were found in clumps with indefinite pounders and mostly over lapping each other. The nucleoli of this cells showed atypia with vesicular nucleoli forming empty glass appearance, with dark nucleoli, psammome bodies were identified in all cases and were often associated with the papillary component, either within fibrovascular cores or lining epithelium, infiltration of mononuclear cells, haemorrhage, necrosed detached tumor cells, and odema was detected in the affected lungs.

In this study Strep suis (S. suis), Bacillus sp and Staph aureus (S. aureus) were isolated from lungs affected with papillary carcinoma, the isolation of these bacteria may have an importance in the future studies to determine the relationship between bacteria and such tumor.

Conclusion: The current study considered to be the first report for occurrence of pulmonary papillary carcinoma in dromedary camel in Sudan.