Pantoprazole-Domperidone Induced Hyperprolactinemia and Galactorrhea in a Chronic Kidney Disease Patient on Dialysis

Pantoprazone-Domperidone fixed-dose combinations are commonly used in End Stage Renal Disease (ESRD) patients on dialysis. The medication helps in control of drug induced gastritis that can occur due to several medications including oral calcium and iron supplements. Besides this the pantoprazole-domperidone combination helps in treatment of uremic gastritis, peptic ulcer disease, and gastroesophageal reflux disease.

Rarely, pantoprazole and domperidone may induce galactorrhea. We report a case of a female patient on dialysis who developed drug induced hyperprolactinemia and galactorrhea due to therapeutic dose of a fixed-dose combination of pantoprazole (40 mg) and domperidone (30 mg), used for treatment of gastritis- the duration of therapy being 4 months. Galactorrhea subsided after discontinuation of pantoprazole-domperidone.