Biocatalysed Stereoselective Synthesis of Chiral Nitro Alcohols

Salokhe, Prabha R. and Salunkhe, Rajeshri S. (2023) Biocatalysed Stereoselective Synthesis of Chiral Nitro Alcohols. In: Progress in Chemical Science Research Vol. 7. B P International, pp. 105-112. ISBN 978-81-19102-39-6

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Abstract

Chiral nitro alcohols are versatile intermediates used in the synthesis of important pharmaceuticals and chiral synthones. During the past decade, the search for greener and more sustainable synthetic procedures has promoted the investigation of biocatalysed strategies for the synthesis of enantiopure nitro alcohols. In this article, stereoselective synthesis of chiral nitro alcohols by biocatalytic reduction of acetophenone and 2-, 3-, 4-nitro acetophenone, 3-nitro-4-methyl acetophenone and 3-nitro propiophenone was accomplished using Rhizopus arrhizus NCIM 878 to yield corresponding (S) -nitro alcohols in good yield and ee (70-87%). However, the biotransformation is very sensitive to the effect of substituent methyl group on aromatic ring and on side chain which proves its structure-activity relationship.

Item Type: Book Section
Subjects: Open Research Librarians > Chemical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 30 Sep 2023 11:55
Last Modified: 30 Sep 2023 11:55
URI: http://stm.e4journal.com/id/eprint/1587

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