Haploinsufficiency for Steroidogenic Factor 1 Affects Maternal Behavior in Mice

Spanic, Tanja and Grgurevic, Neza and Majdic, Gregor (2016) Haploinsufficiency for Steroidogenic Factor 1 Affects Maternal Behavior in Mice. Frontiers in Behavioral Neuroscience, 10. ISSN 1662-5153

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Abstract

Steroidogenic factor 1 (SF-1), officially designated NR5A1, is essential for gonadal and adrenal development and for the normal structure of the ventromedial hypothalamus (VMH), as demonstrated by SF-1 knockout mice (SF-1 KO), but much less is known about the possible effects of haploinsufficiency of the SF-1 gene. In the present study, maternal behavior in SF-1 KO heterozygous mice was evaluated. Behavioral tests revealed that SF-1 KO heterozygous females have impaired maternal behavior. In comparison to wild-type (WT) females, SF-1 KO heterozygous females retrieved significantly fewer pups into their nests, latency to retrieve and crouch over the pups was longer, and their nests were lower quality. As suggested by previous studies full dosage of SF-1 gene is needed for appropriate stress response and expression of brain-derived neurotrophic factor (BDNF) in the brain, and this might present a mechanism through which maternal behavior in SF-1 KO heterozygous females is impaired.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 25 Feb 2023 11:48
Last Modified: 19 Feb 2024 04:16
URI: http://stm.e4journal.com/id/eprint/224

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