Assessment of the Microbial Flora of the Genital Tract and the Morphofunctional State of the Endometrium in Antiphospholipid Syndrome

According to the World Health Organization (WHO), an increased rate of loss of desired pregnancies determines not only the medical but also the social significance of the problem of miscarriage. Among the multiple causes of miscarriage, about 55-62% are defects in coagulation proteins or platelets, one of the manifestations of which is antiphospholipid syndrome (APS). The primary purpose of the study is to assess the microbial flora of the genital tract and the morphological and functional state of the endometrium in women with antiphospholipid syndrome (APS) in order to study the interaction between the pathogenesis of APS and the inflammatory process. To assess the condition of women, the somatic and reproductive anamnesis, heredity, the nature of the diseases suffered, and the formation of menstrual and generative functions of women, including the outcomes of pregnancies (childbirth, spontaneous abortions, ectopic pregnancy) were studied. Currently, the available literature data indicate that the formation of obstetric and perinatal pathology largely depends on the presence of an infectious process in the mother. Since the main trigger mechanism in the development of inflammation is microbial invasion, a study of the bacteriological contamination of the genital tract and endometrium in women with antiphospholipid syndrome (AFS) was conducted. Research has shown that despite the presence of infection in women with APS, infectious agents are not pathogenetic in the complicated course of APS, which could lead to increased production of antiphospholipid antibodies.