Thymic stromal lymphopoietin: Next research hotspot of carcinogenesis?

Wu, Tong and Wang, Juan and Jia, Lihua and Cheng, Bin (2012) Thymic stromal lymphopoietin: Next research hotspot of carcinogenesis? Advances in Bioscience and Biotechnology, 03 (06). pp. 665-668. ISSN 2156-8456

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Abstract

Thymic stromal lymphopoietin (TSLP) is an epithetlial cell derived cytokine which has been reported to be a master regulator in T helper (Th) 2 driven inflammation. Through acting on dentritic cells (DCs), granulocytes, natural killer T cells or directly on CD4+ T cells, TSLP plays significant roles in the pathogenesis of atopic diseases consisting of the triad of asthma, allergic rhinitis and atopic dermatitis. Recently mounting evidence demonstrated that cancer-related inflammation play decisive roles at different stages of tumor development, including initiation, promotion, malignant conversion, invasion, and metastasis. As a crucial regulator of Th2 driven inflammation, the involvement of TSLP in carcinogenesis have attracted researchers’ attention. However, the mechanisms of TSLP’s involvement in carcinogenesis are still largely unknown. In this review we first outline the roles of TSLP involved in allergic inflammation and then we further focus on the recent findings on TSLP’s tumor promoting activities hoping to provide hints on elucidation of the TSLP implication in carcinogenesis in future studies.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 22 Mar 2023 10:06
Last Modified: 07 May 2024 04:45
URI: http://stm.e4journal.com/id/eprint/438

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