Initiation and Regulation of CNS Autoimmunity: Balancing Immune Surveillance and Inflammation in the CNS

Harris, Melissa G. and Fabry, Zsuzsanna (2012) Initiation and Regulation of CNS Autoimmunity: Balancing Immune Surveillance and Inflammation in the CNS. Neuroscience and Medicine, 03 (03). pp. 203-224. ISSN 2158-2912

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Abstract

While the central nervous system (CNS) was once thought to be immune privileged, more recent data support that certain areas of the healthy CNS are routinely patrolled by immune cells. Further, antigen drainage is another means by which the adaptive arm of the immune system can gain information about the health of the CNS. Altogether these ensure that the CNS is not beyond the scope of immune protection against viruses and tumors. However, immune surveillance in the CNS has to be tightly regulated, as CNS autoimmune disease and inflammation may arise from increased immune cell infiltration. In this review we discuss the concept and implications of CNS immune surveillance and introduce the CNS antigen-presenting cells (APCs) that potentially regulate neuroinflammation and autoimmunity. We also discuss novel animal models in which CNS disease initiation and the role of APCs in disease regulation can be tested.

Item Type: Article
Subjects: Open Research Librarians > Medical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 10 Feb 2023 12:18
Last Modified: 28 Sep 2023 09:36
URI: http://stm.e4journal.com/id/eprint/52

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