Laxative Effects of Aqueous Extract of Sida acuta Leaves in Loperamide- Induced Constipation in Wistar Rats

Aim: To investigate the laxative potentials of aqueous leaf extract of Sida acuta in loperamide-induced constipation in Wistar rats.

Methods: Constipation was induced by oral administration of loperamide (3 mg/kg b.wt.). The constipated rats were orally treated daily either with 200, 400, 800 mg/kg body weight per day of the extract or 0.21 mg/kg bisacodyl (reference drug) for 7 days while the normal and constipated control groups received distilled water. The feeding characteristics, body weight, faecal properties and gastrointestinal transit ratio were monitored throughout the study period.

Results: There was significant decrease (p < 0.05) between normal and constipated rats in the number of faecal pellets and water content of faecal pellets while there was no significant changes in the feed/ water intake and body weight of rats .Administration of the graded doses of the extract to the constipated rats significantly and dose- dependently normalized (p < 0.05) the number of faecal pellets/ water content of faecal pellets and gastrointestinal ratio compared to the constipated control.

Conclusion: The aqueous root extract of Sida acuta possesses laxative activity in loperamide- induced constipated rats.