Synthesis Spectroscopy and Computational Studies of Manganese (II) Complexes Incorporating (N,O)(O,O`) Ligands and Their Biological Activity

Manganese (II) complexes were synthesized via the reaction equimolar quantity of Manganese(II) chloride-hydrate (MnCl2.6H2O) with Chiral saccharides such {(OH)5(CH2)(C5H5)O} or {(OH)6(CH2)(C5H5)O} and (C9H7NO) as secondary ligands [Mn(C9H7NO){(OH)5(CH2)(C5H5)O}]Cl2 (C1), [Mn(QH){(OH)6(CH2)(C5H5)O}]Cl2 (C2), respectively where (C9H7NO) is 8-hydroxyquinoline, {(OH)5(CH2)(C5H5)O} Dextrose (Dex), {(OH)6(CH2)(C5H5)O} fructose (fru). Theses complexes were characterized by UV-vis, IR spectroscopy, tandem mass spectrometry and elemental analysis.

The complexes have been found to have square planer geometry as the optimization method. The molecular geometries obtained from XRD data.

The pre-optimized to standard convergence criteria using the basis Minimize Energy to Minimum.

The isolated compounds were screened for its antibacterial activity against six standard human pathogens (Staphylococcus aureus, Streptococcus spp., Escherichia coli, Klebsiella spp., Psuedomones spp. and Protues spp.) and the results were obtained. About 10 to 70% for complex (C1) and about 10 to 60% for complex (C2) of the activity.