Assessment of Antiplasmodial and Anti-anaemic Activities of Hoslundia opposita, an Ivorian Medicinal Plant

Moustapha, Karamoko and Karim, Tuo and Offianan, Toure and Sylvain, Beourou and David, Attemene and Albert, Gnondjui and Stéphane, Yao and Philippe, Bidie (2018) Assessment of Antiplasmodial and Anti-anaemic Activities of Hoslundia opposita, an Ivorian Medicinal Plant. Journal of Advances in Microbiology, 11 (1). pp. 1-11. ISSN 24567116

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Abstract

Aims: The aim of this study was to investigate the antiplasmodial and anti-anaemic activities of different extracts of Hoslundia opposita

Place and Duration of Study: This study was carried out from March to November at Institut Pasteur of Côte d’Ivoire.

Methodology: Extracts of Hoslundia opposita were prepared using various solvents. The in vitro antiplasmodial activity was investigated on both clinical isolates and Chloroquine-resistant K1 strain of Plasmodium falciparum, using SYBR green I based assay. Moreover, the anti-anaemic activity was assessed on phenyl hydrazine induced anaemia in albino rats.

Results: Two (2) among the five (5) extracts were not active. However, the hydroethanolic, aqueous and ethyl acetate extracts exhibited a moderate (IC50= [22.88 – 49.65] μg/mL), promising (IC50= [5.99 – 12.1] μg/mL), and very active (IC50= 1.57 μg/mL) on clinical isolates. The hydroethanolic and aqueous extracts showed a promising antiplasmodial activity (IC50= 11.68 and 12.23 μg/mL respectively) on Chloroquine-resistant K1 strain of P. falciparum. Whereas, the ethyl acetate extract exhibited a potent activity (IC50= 0.78 μg/mL) on it. Extract showing good antiplasmodial activity were used for in vivo anti-anaemic test. Among selected extracts, the hydroethanolic extract was the most active with hematologic recovery percentages better than those of vitamin B12.

Conclusion and Prospect: Hoslundia opposita could be a potential source for new antimalarial drugs. Furthermore, this plant extract might be used as an improved traditional medicine.

Item Type: Article
Subjects: Open Research Librarians > Biological Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 12 May 2023 08:52
Last Modified: 18 Mar 2024 03:57
URI: http://stm.e4journal.com/id/eprint/784

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