Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study

Kakaei, Farzad and Mirabolfathi, Saba and Yavari, Negin and Ardalan, Mohammad Reza and Mozafar, Mehrdad and Zarrintan, Sina (2021) Hereditary thrombophilia and thrombosis of tunneled hemodialysis catheters: A single center study. Journal of Cardiovascular and Thoracic Research, 13 (1). pp. 79-83. ISSN 2008-5117

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Abstract

Introduction: Vascular access thrombosis increases the risk of mortality and morbidity in end-stage renal disease (ESRD) patients on hemodialysis (HD). This study aimed to evaluate hereditary thrombophilia factors in HD patients and its association with tunneled cuffed catheters’ thrombosis.

Methods: In this cross-sectional study, 60 consecutive patients with ESRD on HD with tunneled cuffed catheters were selected. Inherited thrombophilia factors (Anti-thrombin III, Protein C, Protein S, and Factor V Leiden) were measured and the patients were followed for 3 months to evaluate the incidence of catheter-related thrombosis. The association between these factors and catheter thrombosis was assessed.

Results: The mean age of patients was 60.30 ± 8.69 years. Forty-seven patients (78.30%) were female and thirteen patients (21.70%) were male. The most common cause of ESRD was diabetes mellitus (41.67%). The most catheter site was the right internal jugular vein (55%). There were 22 (36.67%) and 8 (13.33%) cases of thrombosis and mortality, respectively. The association between hereditary thrombophilia factors and catheter thrombosis was not statistically significant (P > 0.05).

Conclusion: In this small group of our patients, the frequency of hereditary thrombophilia was not significantly different between those with and without thrombosis of tunneled HD catheter.

Item Type: Article
Subjects: Open Research Librarians > Medical Science
Depositing User: Unnamed user with email support@open.researchlibrarians.com
Date Deposited: 05 May 2023 11:43
Last Modified: 23 Dec 2023 08:25
URI: http://stm.e4journal.com/id/eprint/849

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